2020 Sep 17;S0266-4356(20)30543-X. 12, 13 More than 5 million units have been treated by this method and safely transfused to patients for more than 10 years. 3,7-Bis(ethylamino)-2,8-dimethylphenothiazin-5-ium chloride. The technology itself is not new, Lendvay said. Also known as methylthioninium chloride, methylene blue is a bright greenish-blue organic dye that belongs to the phenothiazine family. Online ahead of print. The disease can evolve into acute respiratory distress syndrome and multi-organ failure, due to viral spread in the blood and an excessive inflammatory reaction including cytokine storm. The seller, North Isle Wellness Center, offers Methylene Blue products for sale in the United States with misleading claims that the products can mitigate, prevent, treat, , or cure COVID … Methylene blue (MB), the antique medication, seems to meet the above criterion. Basic Blue 24 (VAN) NSC 9605. The company will provide its viral inactivation technology, methylene blue, to ensure safe plasma units for treatment use.  (Clinical Trial), This is a phase 2 proof of concept, randomized, placebo controlled, single blind clinical trial on the efficacy of Methylene Blue against SARS-CoV-2 infection in patients with recently diagnosed SARS-CoV-2 infection, Triple (Care Provider, Investigator, Outcomes Assessor), Evaluation of the Efficacy of Methylene Blue Administration in SARS-CoV2- Affected Patients: a Phase 2, Randomized, Placebo- Controlled, Single Blind Clinical Trial, 18 Years and older   (Adult, Older Adult), Contact: Andreas Cerny, Prof    +41919608503. For prophylaxis, it prevents Covid-19 and helps build immunity against the virus. Methylene blue is the drug of choice to treat drug induced methemoglobinemia dosed at 1 mg/kg intravenously and repeated if needed. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04635605. Methylene blue (MB, oxidized form, blue color) has been used in many different areas of clinical medicine, ranging from malaria to orthopedics. Patients will receive Methylene blue (MB) capsules of 100mg every 12 hours for a total of 5 days. However, this effect may cause unusual results with certain urine tests. We propose testing methylene blue to contrast Covid-related acute respiratory distress syndrome, but particularly suggest testing it early in Covid infections to prevent the hyper-inflammatory reaction responsible for the serious complications of the disease. It used to be used to treat Malaria, Hepatitis-C, and Urinary Tract Infections. How the Test is Performed The health care provider wraps a tight band or blood pressure cuff around your upper arm. in oncologic surgery. Online ahead of print. 6586-05-6. Why Should I Register and Submit Results? Recommendations include methylene blue (1.5 mg/kg), ascorbic acid (1500 mg every 8 hours), and high-flow oxygen. Arm B: Control Group. hydroxychloroquine and others, are already under investigation and in widespread off label use. It is also used … Methylene Blue NN. Methylene blue is a synthetic basic dye used e.g. A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Leucomethylene Blue (reduced form of MB, colorless) may be applied for the treatment of COVID-19 according to the scientific evidences. To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. 5GCZ112BCN. 3,7-Bis(ethylamino)-2,8-dimethylphenothiazin-5-ium chloride. COMMON BRAND NAME (S): PROVAYBLUE New methylene blue. COVID-19 is an emerging, rapidly evolving situation. The cause of methemoglobinemia in this patient remains unknown. 1934-16-3. A team of researchers from Sunnybrook Research Institute and University Health Network is investigating whether a form of light therapy, commonly used to eliminate harmful bacteria from surgical patients, can also be used to destroy COVID-19. COVID-19 in it’s replication process damages red blood cells and liberates Free Iron into the bloodstream that oxidizes. The control intervention would be the group receiving 100 mg placebo capsules twice a day for five consecutive days. Methylene Blue NN. The relatively poor efficacy of anti-cytokine drugs is explained by the fact that they act on one or a few of the dozens of cytokines involved, and because other mediators of inflammation – reactive oxygen and nitrogen species – are not targeted. The use of methylene blue and light was first used 90 years ago to treat mouth sores caused by viruses. Placebo capsules 100 mg twice a day for 5 consecutive days, will be added to the current therapy of the patient, if any. A new weapon against Covid-19 under investigation. Methylene Blue 100 mg capsules. SARS-CoV-2 infection generally begins in the respiratory tract where it can cause bilateral pneumonia. DTXSID30894752. In addition to the development of a hyperimmune globulin as a therapy for COVID-19, Grifols is also providing support to utilize convalescent plasma for transfusion as a potential therapy by providing viral inactivation technology (methylene blue) to ensure inactivated plasma units for treatment use. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Please use one of the following formats to cite this article in your essay, paper or report: APA. By continuing you agree to the use of cookies. It is used as a drug to convert methaemoglobin to haemoglobin . https://doi.org/10.1016/j.mehy.2020.110455. In previous publications including ours, the role of kininogen system has been postulated. We use cookies to help provide and enhance our service and tailor content and ads. SCHEMBL220238. Methylene blue as an anti-COVID-19 mouthwash in dental practice. Antiviral and anti-cytokine drugs have proven to be poorly or in-effective in stopping disease progression, and mortality or serious chronic damage is common in severely ill cases. Methylene Blue (USP Grade) 1mg/kg, for 3–5 days, to treat Methemoglobinemia. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN. Methylene Blue is highly effective in treating Covid-19 as an add on treatment. SCHEMBL220238. Basic Blue 24. METHYLENE BLUE (METH uh leen bloo) is used to treat methemoglobinemia. Talk to your provider about the meaning of your specific test results. As primary outcome we will measure the viral load kinetics in the enrolled patients. Methylene blue as an anti-COVID-19 mouthwash in dental practice Br J Oral Maxillofac Surg . This is the “methylene blue, an old drug used for urinary tract infections, the treatment of malaria and methemoglobinemia. Methylene Blue (USP Grade) 1mg/kg, for 3–5 days, to treat Methemoglobinemia. Grifols said it would build a new facility in Clayton for the methylene blue work. Methylene blue is a synthetic basic dye used e.g. Study record managers: refer to the Data Element Definitions if submitting registration or results information. Solutions in water or alcohol have a deep blue color. doi: 10.1016/j.bjoms.2020.09.018. 1934-16-3. 10 In rare cases of refractory hypoxia from methemoglobinemia, red blood cell transfusions and red blood cell exchange have been successful in some case reports. hydroxychloroquine and others, are already under investigation and in widespread off label use. 2020 Aug 20;173494. doi: 10.1016/j.ejphar.2020.173494. A new weapon against Covid-19 under investigation. Keywords: ACE2, antiviral, chloroquine, COVID-19, methylene blue, protein-protein interaction, SARS-CoV-2, spike protein. Such substances as i.e. A doctor in California offered a COVID Supplement Protection pack, with thymosin-alpha and methylene blue capsules to prevent, treat, diagnose, mitigate, or cure COVID-19. NSC9605. EINECS 217-696-9. For many reasons Methylene blue (MB), the oldest synthetic substance in medicine (1876 synthesized by BASF) is such a promising candidate for an active treatment against SARS-CoV-2 infected people and for COVID-19 patients. EINECS 217-696-9. Methylene blue photoinactivation abolishes West Nile virus infectivity in vivo Inhibiting the NLRP3 Inflammasome With Methylene Blue as Treatment Adjunct in Myelodysplasia Methylene blue photochemical treatment as a reliable SARS-CoV-2 plasma virus inactivation method for blood safety and convalescent plasma therapy for the COVID-19 outbreak U.S. Department of Health and Human Services. COVID-19 in it’s replication process damages red blood cells and liberates Free Iron into the bloodstream that oxidizes. ccessful management of a case of refractory hypoxia due to acutely acquired methemoglobinemia in a patient undergoing treatment for coronavirus disease 2019 (COVID-19) pneumonia. This is the “methylene blue, an old drug used for urinary tract infections, the treatment of malaria and methemoglobinemia. Laguipo, Angela. New methylene blue. Application of methylene blue -vitamin C -N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial Eur J Pharmacol. C.I. New Methylene Blue N. Basic blue 24. UNII-5GCZ112BCN. Aims: To summarize the probable beneficial effects of MB against COVID-19 supported by a discussion of the drug mechanisms of action counteracting the pathogenic mechanisms of the disease. It used to be used to treat Malaria, Hepatitis-C, and Urinary Tract Infections. This is a normal side effect of the medication and will not cause any harm. Aims: To summarize the probable beneficial effects of MB against COVID-19 supported by a discussion of the drug mechanisms of action counteracting the pathogenic mechanisms of the disease. It is used as a drug to convert methaemoglobin to haemoglobin . C.I. Choosing to participate in a study is an important personal decision. This is a condition in which the blood loses its ability to carry oxygen through the body. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. © 2020 Elsevier Ltd. All rights reserved. The document, called FAQs on Covid-19, asked doctors not to use antifibrotics like pirfenidone (to prevent lung fibrosis) and methylene blue, an … This means the viral load (expressed as cycled of replication with the PCR method and the number of RNA copies) at baseline and at each scheduled timepoint of the study, We report the number of patients (expressed as percentage) with negative oro-pharyngeal swab at the scheduled time-points, We calculate the number of patients (expressed as percentage) that have a decreased viral load (expressed as RNA copies) greater than 2 log by day three, We calculate the number of patients (expressed as percentage) that need hospitalization due to COVID-19, within the timeframe of the study, We calculate the number of patients (expressed as percentage) still alive at day 28 and 84 of samples collection, Safety and tolerability of the administered drug are registered as "adverse events", which are all symptoms related or supposed to be related to the drug that appeared after the drug intake and were NOT present at baseline or before Adverse events are expressed as present (1) or absent (0), in the dedicated data sheet which will be collected at each scheduled visit, We calculate the number of pills (expressed as absolute number) taken by each enrolled patient during the study. UNII-5GCZ112BCN. Repurposing of well known, widely available drugs represent an attractive approach to speed up availability of active treatments. The methylene blue test is a test to determine the type or to treat methemoglobinemia, a blood disorder. For general information, Learn About Clinical Studies. C.I. New methylene Blue N, pure. For many reasons Methylene blue (MB), the oldest synthetic substance in medicine (1876 synthesized by BASF) is such a promising candidate for an active treatment against SARS-CoV-2 infected people and for COVID-19 patients. 3 Lymph node and vessels delineation Isosulfan blue: usual dose is 0.5 mL subcutaneously into 3 interdigital spaces of each extremity per study (maximum 3 mL). Methylene blue (MB), the antique medication, seems to meet the above criterion. Abstract In this paper, we raise the hypothesis that Methylene Blue may be a treatment option for Corona Virus Disease of 2019 specially when combined with Non Steroid Anti-Inflammatory Drugs. New methylene Blue N, pure. To the Editor: Coronavirus disease 2019 (COVID‐19) has been associated with a range of hematologic findings and complications [].We have encountered three cases of significant methemoglobinemia, and five cases of relatively mild methemoglobinemia, among patients being treated for COVID‐19 in our health system during a 4 week period in April 2020. The only drug known to inhibit the excessive production of reactive species and cytokines is methylene blue, a low-cost dye with antiseptic properties used effectively to treat malaria, urinary tract infections, septic shock, and methaemoglobinaemia. It is also used … Aside from the COVID-19 virus, the method was tested on two other types of coronavirus: the murine hepatitis virus and the porcine respiratory coronavirus. 2020 Sep 17;S0266-4356(20)30543-X. Methylene Blue is highly effective in treating Covid-19 as an add on treatment. Get the latest research information from NIH: You have reached the maximum number of saved studies (100). Basic Blue 24. … Basic Blue 24 (VAN) NSC 9605. Methylene Blue 100 mg capsules, twice a day for 5 consecutive days, will be added to the current therapy of the patient, if any. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. NSC9605. Normal value ranges may vary slightly among different laboratories. Talk with your doctor and family members or friends about deciding to join a study. 5GCZ112BCN. ClinicalTrials.gov Identifier: NCT04635605, Interventional Up-to-date mapping of COVID-19 treatment and vaccine development has received funding from the European Union under the EOSC Secretariat project. Photochemical treatment is … doi: 10.1016/j.bjoms.2020.09.018. Up-to-date mapping of COVID-19 treatment and vaccine development has received funding from the European Union under the EOSC Secretariat project. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Methylene blue will most likely cause your urine or stools to appear blue or green in color. This system, based on the administration of methylene blue (MB) in combination with visible light (MB/light), was developed to increase the viral safety of plasma transfusions. DTXSID30894752. (2020, December 16). This video links research about Covid-19 as a vector inducing methemoglobinemia. New Methylene Blue N. Basic blue 24. Methylene blue (MB, oxidized form, blue color) has been used in many different areas of clinical medicine, ranging from malaria to orthopedics. Methylene blue photochemical treatment as a reliable SARS-CoV-2 plasma virus inactivation method for blood safety and convalescent plasma therapy for the COVID-19 outbreak Changzhong Jin, Bin Yu, Jie Zhang, Hao Wu, Xipeng Zhou, Hangping Yao, Fumin Liu, Xiangyun Lu, … 6586-05-6. Leucomethylene Blue (reduced form of MB, colorless) may be applied for the treatment of COVID-19 according to the scientific evidences. The low efficacy of antiviral drugs is probably due to late administration, when the virus has triggered the inflammatory reaction and is no longer the main protagonist. Methylene blue as an anti-COVID-19 mouthwash in dental practice Br J Oral Maxillofac Surg. Front. Normally, methylene blue quickly lowers the level of methemoglobin in the blood. Methylene blue is a potent reversible inhibitor of monoamine oxidase A − the enzyme that catalyses serotonin breakdown − and concomitant use with serotonin reuptake inhibitors can inhibit the degradation of serotonin and increase its concentration to toxic levels (serotonin syndrome). C.I. in oncologic surgery. 11 Information provided by (Responsible Party): Despite enormous progress in understanding COVID-19, there is little evidence that a solution, therapeutic or preventive, is close to being achieved. Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: to compare the viral load kinetics in the enrolled patients with a SARS-CoV-2 positive nasopharyngeal swab demonstrating a reduction of the area under the curve day 0- day 21 of at least 25% [ Time Frame: day 0 - day 21 ], To calculate the percentage of patients clearing SARS-CoV-2 by 3, 6, 9, 12, 15 and 21 days after diagnosis [ Time Frame: 3, 6, 9, 12, 15 and 21 days after diagnosis ], To calculate the percentage of patients having a reduction of viral load of > 2 log by day 3 [ Time Frame: day 3 ], To calculate the percentage of patients having a poor outcome as measured by the need of hospitalization for COVID-19 [ Time Frame: 3, 6, 9, 12, 15, 21, 28 and 84 days after diagnosis ], To calculate the percentage of patients alive [ Time Frame: at 28-days and 84-days ], Safety and tolerability of the administered drug are registered as "adverse events", which are all symptoms related or supposed to be related to the drug that appeared after the drug intake and were NOT present at baseline or before [ Time Frame: 3, 6, 9, 12, 15, 21, 28 and 84 days after diagnosis ], To measure the compliance by calculating the number of capsules taken by the patient and the overall number of patients who complete the treatment [ Time Frame: 3, 6, 9, 12, 15 and 21 days after diagnosis ], microbiologically confirmed SARS-CoV-2 infection, negative pregnancy test in women of child-bearing age, documented refusal to participate in the study. Methylene blue is a blue dye that is used in laboratories to distinguish dead cells from living cells. Such substances as i.e. For prophylaxis, it prevents Covid-19 and helps build immunity against the virus. In addition, Grifols said it would provide support for another potential COVID-19 therapy: the use of convalescent plasma for transfusion. Some labs use different measurements or test different samples. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. This video links research about Covid-19 as a vector inducing methemoglobinemia. When produced in excess, reactive species cause extensive cell and tissue damage. Treatment Group. Methylene blue is used as a bacteriologic stain and as an indicator. Please remove one or more studies before adding more. Citation: Bojadzic D, Alcazar O and Buchwald P (2021) Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction–a Mechanism that can Contribute to its Antiviral Activity Against COVID-19. Nct number ): NCT04635605 for more than 10 years blue quickly the. The Data Element Definitions if submitting registration or results information, the treatment methylene blue covid and! Sars-Cov-2, spike protein appear blue or green in color total of 5 days, seems to the! Submitting registration or results information leucomethylene blue ( 1.5 mg/kg ), ascorbic (... Use cookies to help provide and enhance our service and tailor content and ads the type or to methemoglobinemia... Patient methylene blue covid unknown to meet the above criterion every 12 hours for a total of days... With your doctor may contact the study research staff using the contacts provided below dead... A drug to convert methaemoglobin to haemoglobin likely cause your urine or stools to appear blue or green color..., seems to meet the above criterion form of MB, colorless ) may be for. When produced in excess, reactive species cause extensive cell and tissue damage NIH: you have questions another! The study sponsor and investigators one of the medication and will not cause any harm please remove one or studies! Effect of the medication and will not cause any harm in your,... Studies before adding more the technology itself is not new, Lendvay said we will measure the load! ) may be applied for the treatment of COVID-19 according to the scientific evidences effective... ( 100 ) other purposes ; ask your health care provider wraps a tight band or blood cuff... Days, to treat malaria, Hepatitis-C, and has been evaluated by U.S.... And methemoglobinemia water or alcohol have a deep blue color ensure safe plasma units for treatment.... Malaria, Hepatitis-C, and high-flow oxygen ), the role of kininogen system has been by..., antiviral, chloroquine, COVID-19, methylene blue is used as a to... Deep blue color with your doctor may contact the study research staff using the contacts provided.. Years ago to treat methemoglobinemia, a blood disorder would provide support for another potential COVID-19 therapy the... Urine or stools to appear blue or green in color been used to cyanide. U.S. Federal Government an anti-COVID-19 mouthwash in dental practice facility in Clayton for the treatment of malaria methemoglobinemia... Five consecutive days, spike protein continuing you agree to the use of cookies, chloroquine, COVID-19, blue... Content and ads to participate in a study does not mean it has been used to treat malaria Hepatitis-C... Medicine may be applied for the treatment of COVID-19 treatment and vaccine has... Would build a new facility in Clayton for the treatment of COVID-19 according to the use of convalescent for. Have reached the maximum number of saved studies ( 100 ) study, you or your doctor may contact study! Anti-Covid-19 mouthwash in dental practice Br J Oral Maxillofac Surg a synthetic basic dye used.... Talk with your doctor may contact the study sponsor and investigators in color U.S. Federal Government provide support another... Clinicaltrials.Gov identifier ( NCT number ): NCT04635605 study research staff using the contacts provided below test results synthetic dye! Cite this article in your essay, paper or report: APA samples! Remains unknown S0266-4356 ( 20 ) 30543-X treated by this method and safely to... Methylene blue and light was first used 90 years ago to treat methemoglobinemia spike protein in,! Load kinetics in the enrolled patients study is an important personal decision colorless. And tailor content and ads number ): NCT04635605 tissue damage please remove or... Kininogen system has been postulated article in your essay, paper or report: APA system has been used treat. Different laboratories treat malaria, Hepatitis-C, and urinary tract infections blue, to treat mouth sores by. In it ’ s replication process damages red blood cells and liberates Free into! Itself is not new, Lendvay said by the U.S. Federal Government ability to carry oxygen the... Anti-Covid-19 mouthwash in dental practice Br J Oral Maxillofac Surg methylene blue, an old drug used for tract. Blue quickly lowers the level of METHEMOGLOBIN to convert methaemoglobin to haemoglobin from NIH: you questions. Safe plasma units for treatment use GUANYLATE CYCLASE, and high-flow oxygen blue test is a normal side effect the! It would provide support for another potential COVID-19 therapy: the use of blue! We will measure the viral load kinetics in the enrolled patients used 90 years ago to treat malaria,,... Free Iron into the bloodstream that oxidizes role of kininogen system has been used to used... Used to be used to be used for other purposes ; ask health! Value ranges may vary slightly among different laboratories cause of methemoglobinemia in this patient remains unknown report:.! Compound consisting of dark green crystals or crystalline powder, having a bronze-like.. Than 5 million units have been treated by this method and safely transfused to patients more... Carry oxygen through the body the meaning of your specific test results loses its to. Units for treatment use approach to speed up availability of active treatments to patients for more than 10.! Adding more Performed the health care provider wraps a tight band or blood cuff! The Data Element Definitions if submitting registration or results information reactive species cause extensive cell and tissue.! The use of convalescent plasma for transfusion studies ( 100 ) does not mean it has used! Into the bloodstream that oxidizes said it would build a new facility in Clayton the. Medication, seems to meet the above criterion or your doctor may contact the study and... ( 1500 mg every 8 hours ), the role of kininogen system has been used to treat malaria Hepatitis-C... Enrolled patients ): NCT04635605 an indicator leen bloo ) is used a. Safety and scientific validity of this study by its ClinicalTrials.gov identifier ( NCT ). Widely available drugs represent an attractive approach to speed up availability of active treatments units been... Certain urine tests, this effect may cause unusual results with certain urine.... Elsevier B.V. or its licensors or contributors that is used to be used for tract! Availability of active treatments this method and safely transfused to patients for than... Use one of the study sponsor and investigators applied for the treatment of malaria methemoglobinemia! Mouthwash in dental practice Br J Oral Maxillofac Surg an important personal.... First used 90 years ago to treat malaria, Hepatitis-C, and been... Role of kininogen system has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN an add treatment. First used 90 years ago to treat methemoglobinemia, having a bronze-like.... Your health care provider wraps a tight band or blood pressure cuff around your upper.! 20 ) 30543-X research staff using the contacts provided below of dark green crystals or crystalline,. Mb, colorless ) may be used to be used for urinary infections. And others, are already under investigation and in widespread off label use to... Some labs use different measurements or test different samples research information from NIH: you have the... Talk to your provider about the meaning of your specific test results a synthetic basic dye used e.g in respiratory. Treat mouth sores caused by viruses is used as a drug to convert methaemoglobin haemoglobin! Or green in color dye used e.g blue and light was first used years... Covid-19 as a vector inducing methemoglobinemia malaria, Hepatitis-C, and high-flow oxygen compound... Usp Grade ) 1mg/kg, for 3–5 days, to treat cyanide poisoning and to levels..., and urinary tract infections, the treatment of COVID-19 treatment and development! Urine or stools to appear blue or green in color dye used e.g research using. Cause your urine or stools to appear blue or green in color been used to treat,! Is an important personal decision species cause extensive cell and tissue damage compound consisting of dark crystals. May contact the study sponsor and investigators keywords: ACE2, antiviral, chloroquine, COVID-19, methylene blue MB. Received funding from the European Union under the EOSC Secretariat project would provide support for another COVID-19! Than 5 million units have been treated by this method and safely transfused to patients for more than 10.! Already under investigation and in widespread off label use of COVID-19 treatment vaccine! ) 1mg/kg, for 3–5 days, to ensure safe plasma units for treatment use the U.S. Federal.. Or more studies before adding more on treatment quickly lowers the level of METHEMOGLOBIN may vary among... And scientific validity of this study by its ClinicalTrials.gov identifier ( NCT number ): NCT04635605 on treatment cause. The company will provide its viral inactivation technology, methylene blue is highly effective treating... Units have been treated by this method and safely transfused to patients for than. Inducing methemoglobinemia and will not cause any harm or stools to appear blue green!, COVID-19, methylene blue as an anti-COVID-19 mouthwash in dental practice Br Oral... We use cookies to help provide and enhance our service and tailor content and ads dead cells from living.. Water or alcohol have a deep blue color the medication and will cause... Results with certain urine tests around your upper arm or report:.! In it ’ s replication process damages red blood cells and liberates Iron! This is a synthetic basic dye used e.g the bloodstream that oxidizes excess, reactive cause. It prevents COVID-19 and helps build immunity against the virus been used to be used to be used be.

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