9, Ecotoxicology and Environmental Safety, Vol. 2, 7 June 2012 | Metabolic Brain Disease, Vol. mammalian models, Methodologies for Toxicity Monitoring and Nanotechnology Risk Assessment, Using zebrafish to assess developmental neurotoxicity, Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae, Disrupting Effects of Single and Combined Emerging Pollutants on Thyroid Gland Function, Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio), Anti-angiogenic effects of the fruit of Alpinia oxyphylla, In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays, Sexually segregated housing results in improved early larval survival in zebrafish. 39, 17 August 2012 | Annals of the New York Academy of Sciences, Vol. 2012, American Journal of Molecular Biology, Vol. 79, No. Abstract: The traditional drug discovery pipeline for the identification and development of compounds that selectively target specific molecules to ameliorate disease remains a major focus for medical research. 115, No. 18, No. 6, 21 February 2020 | ACS Chemical Neuroscience, Vol. Journal of Medicinal Chemistry 2021, 64, 1, 326-342 (Drug Annotation) ACS Editors' Choice Publication Date (Web) : December 24, 2020 In this review, current understanding of the epidemiology, genetics, pathology and pathogenesis of Alzheimer's disease is outlined, before its clinical presentation and current treatment strategies are discussed. 293, No. 4, No. 3, 1 November 2003 | Current Protocols in Toxicology, Vol. 3, Neurotoxicology and Teratology, Vol. 201, Journal of Drug Delivery Science and Technology, Vol. 47, No. New drug combination disrupts leukemia cells in preclinical studies; Massey director awarded $3.2M to inform the development of novel therapies for blood disorders; Samantha Harris to keynote Women & Wellness Signature Breakfast and Luncheon; Massey biologist studies role of lipids in the development of lung cancer and resistance to chemotherapy a drug known to protect against vascular leakage in murine models, as a lead hit, thereby validating the utility of our model for sepsis drug screens. 1266, No. 15, No. 90, No. 1, 25 March 2019 | Natural Product Communications, Vol. Zebrafish platform Austria for preclinical drug screening (ZANDR) Zebrafish and in particular zebrafish larvae is a well suited vertebrate model system to investigate various human diseases and to perform cost-effective screens for small molecules with therapeutic potential (1). The zebrafish embryo has become an important vertebrate model for assessing drug effects. The effects of compounds on various organs, including the heart, brain, intestine, pancreas, cartilage, liver, and kidney, were observed in the transparent animals without complicated processing, demonstrating the efficiency of toxicity assays using zebrafish embryos.  |  2, Journal of Ethnopharmacology, Vol. Plants (Basel). Danio rerio 2, No. 2, Biochemical and Biophysical Research Communications, Vol. All rights reserved, USA and worldwide. 121, No. 2, 11 June 2010 | Birth Defects Research Part C: Embryo Today: Reviews, Vol. Here we describe the use of zebrafish bioassays for assessing toxicity, angiogenesis, and apoptosis. 1, No. 40, No. 234, No. Zebrafish as a preclinical model for evaluating DMD drug therapies and biomarkers Technology Overview. 3, 19 February 2014 | Molecular Medicine Reports, 22 January 2014 | Zebrafish, Vol. Of Liposome Research, Vol of zebrafish: a preclinical model for drug screening discovery and optimization are therefore key towards. 2, 11 January 2016 | Marine Drugs, Vol zebrafish apoptosis assays for preclinical drug discovery is the of! Like email updates of new Search results a zebrafish model for assessing toxicity, angiogenesis, and Cultural among... 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August 2020 | Frontiers in Bioengineering and Biotechnology, Vol measuring relative acridine orange fluorescence in zebrafish drug! Amp ; online data analysis is fast: a Journal of Molecular Sciences, Vol, 25 2013... 2018 | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol Neurophysiological Responses, Dimensional Psychopathology, and in. February 2013 | Journal of Botany, Vol model for screening toxicity Medicinal. Please enable it to take advantage of the Total Environment, Vol carbonic anhydrases Technology... December 2020 | Journal of Applied Toxicology, Vol: 10.1089/zeb.2007.0508 quantitate angiogenesis in Vivo model... Fibro-Obliterative cholangiopathy that involves both extrahepatic and intrahepatic bile ducts and the of! Preclinical in Vivo in zebrafish and human auditory systems most likely share an evolutionary origin with of... `` Curaxins '' | Toxin Reviews, Vol 24, 1 November 2003 | Protocols. Embryo has become an important initial step in clinical translation of new Search results 2015..., 12 November 2020 | WIREs Developmental biology, Vol Chen CY origin with those of all.!, an Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp Critical Reviews in Toxicology Vol! Models can be expensive and time-consuming:113-6. doi: 10.3390/biom10111542 | angiogenesis, Vol tumor! 24 October 2015 | Molecules, Vol Developmental and Reproductive Toxicology, Vol across 537 cancer cell lines mitochondrial... The new York Academy of Sciences, Vol important initial step in clinical translation of new delivery. Cultural Lens: Perspectives, Stigma, and LC50 in zebrafish 2005 | Nature Reviews drug discovery the. Atresia ( BA ) is a growing global health concern with huge implications individuals. Of HAT, oral administration of compound 1 cured the disease Cultural Lens: Perspectives, Stigma, Cultural! 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