Liu et al critically evaluated the use of endoscopic nasopharyngectomy in the treatment of recurrent NPC. Oncologist. Open Menu. J Buon. (b) The MRI shows the superficial nasopharyngeal recurrence … INTRODUCTION. Thus, a number of strategies to increase the specificity of T-lymphocytes against TAA have been developed, and the most recent is the CAR (chimeric antigen receptors) technology. The interaction between CTLA-4 (present on naïve T-cell) and B7.1 (present on dendritic cells) is able to provoke T-cell anergy. Int J Radiat Oncol Biol Phys. https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf, Creative Commons Attribution - Non Commercial (unported, v3.0) License. Xue C, Huang Y, Huang PY, et al. The objectives of this study were to report the oncologic outcomes and the treatment-related toxicities after reirradiation (re-RT) for recurrent nasopharyngeal … Sometimes radiation therapy, proton beam therapy, or chemotherapy are incorporated into the treatment of recurrent nasopharyngeal carcinoma. If you have (or have had) NPC, you probably want to know if there are things you can do that might lower your risk of the cancer growing or coming back, such as exercising, eating a certain type of diet, or taking nutritional supplements. 2000;54(2):135–142. You may be advised to see your dentist after treatment to check on the health of your teeth. © 2021 American Cancer Society, Inc. All rights reserved. Available from: https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf. This is the time for you to talk to your cancer care team about any changes or problems you notice and any questions or concerns you have. Several strategies of immunotherapy have been developed in the recent years and all of them have a common characteristic: rendering T-cytotoxic lymphocytes the ability to attack the tumor. At the American Cancer Society, we’re on a mission to free the world from cancer. Clinically, we can recognize three main disease presentation settings, namely early stage (T1–N0M0), locally advanced (from T2–N0, until T4–N3M0), and recurrent/metastatic disease, which are also differently approached from a therapeutic point of view. Gnoni A, Silvestris N, Licchetta A, et al. Design of a phase I clinical trial to evaluate intratumoral delivery of ErbB-targeted chimeric antigen receptor T-cells in locally advanced or recurrent head and neck cancer. 2018;36(14):1412–1418. Han F, Zhao C, Huang SM, et al. Unfortunately, it’s not yet clear if there are things you can do that will help. Open access peer-reviewed scientific and medical journals. Get detailed information about the … Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis. 2015;16(6):645–655. Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing. WCRJ. •  Privacy Policy   Nat Rev Clin Oncol. Chin J Cancer. Tax ID Number: 13-1788491. Your doctor will also want to keep a close eye on your hearing, speech, and swallowing, which can be affected by treatment. The conclusion was that TPF triplet chemotherapy showed a high response rate for locoregionally recurrent NPC with an acceptable toxicity profile. Salvage endoscopic nasopharyngectomy for local recurrent or residual nasopharyngeal carcinoma: a 10-year experience. 1991;9(9):1675–1681. Immune checkpoint inhibitor combinations in solid tumors: opportunities and challenges. Cancer Res. In fact, undifferentiated carcinoma, which strongly correlates with Epstein–Barr virus (EBV) infection, is very common in Eastern countries, while squamous cell carcinoma is prevalent in USA and Europe.3. Become a volunteer, make a tax-deductible donation, or participate in a fundraising event to help us save lives. When Your Cancer Comes Back: Cancer Recurrence. VEGF-R overexpression has been found in 60%–67% of patients affected with NPC and is linked to poor prognosis.34 Several oral available multikinase inhibitors have been tested in Phase II clinical trials in patients with recurrent NPC. Gemcitabine plus cisplatin versus fluorouracil plus cisplatin in recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial. Liu T et al: FDG-PET, CT, MRI for diagnosis of local residual or recurrent nasopharyngeal carcinoma, which one is the best? Drug-related adverse events that occurred in 15% of patients included rash (26%), hypothyroidism (18.5%), and fatigue (18.5%), with only one case of sepsis.64 In a similar study, Ma et al in a multinational study evaluated the antitumor activity of nivolumab in patients with NPC who had progressed after a first line of chemotherapy containing platinum. Accelerated beams of heavy, charged particles and protons have a finite range and a distant Bragg peak. After you have completed treatment, your doctors will still want to watch you closely. GP and FP regimens showed the worst results with an ORR of 0.54 and 0.52, respectively. Could I get a second cancer after treatment? Unfortunately, addition of sorafenib to the standard PF regimen has not provided good results in terms of efficacy, activity, and safety in clinical trials.35,36 Sunitinib and pazopanib are two very similar anti-angiogenic drugs, targeting VEGF-R (and also c-KIT in the case of pazopanib), which have been also tested in Phase II trials against recurrent NPC. Until we do, we’ll be funding and conducting research, sharing expert information, supporting patients, and spreading the word about prevention. 2016;8(12):106. 2014;50(5):506–512. 1992;23(4):881–884. A subgroup analysis showed that the proportion of patients who responded was higher among those with PD-L1-positive tumors (at least 1% expression) than those with PD-L1-negative tumors.65. NCCN Guidelines: Head and neck cancer version 2. Notably, none of the triplet combination regimens analyzed in the above-mentioned study contained taxanes associated with platinum, not solving the question concerning the usefulness of taxanes. Imagine a world free from cancer. Adoptive immunotherapy consists instead in the direct administration of a population of tumor-specific antigens that can elicit T-lymphocytes, which have been firstly selected and then rearranged in order to attack the tumor.51 Direct administration of soluble cytokines has been employed for many years, providing limited results. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. The IMRT use and the consequent image guidance have strongly helped to avoid the technical limitations of conventional two- (2D) and three-dimensional (3D) RT, and they have improved the therapeutic ratio of salvage RT. In fact, NPC survivors are at higher risk for getting some other types of cancer. Thanks to the ascent of the precision RT techniques, such as IMRT, local control of primary NPC has been optimized. 2002;8(8):2595–2604. See all references for Nasopharyngeal Cancer. Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma. The efficacy of the re-irradiation, nevertheless, may be counter-balanced by the high toxicity which could arise from the procedure, especially regarding the adjacent neural and mucosal normal structures. Lee AW, Law SC, Foo W, et al. Cao SM, Simons MJ, Qian CN. Able and … Int J Radiat Oncol Biol Phys. 2012;48(17):3198–3204. 10.1055/b-0034-91570 Nasopharyngeal Carcinoma: Salvage of Residual or Recurrent Tumor Incidence and Diagnosis As nasopharyngeal carcinoma is radiosensitive … Our team of expert journalists brings you all angles of the cancer story – from breaking news and survivor stories to in-depth insights into cutting-edge research. Radiother Oncol. Eur J Cancer. World J Clin Oncol. 2015;26(10):1017–1025. •  Associations & Partners   Hui EP, Taylor GS, Jia H, et al. For other people, the cancer might never go away completely. Dove Medical Press is a member of the OAI. 85(3):327-35, 2007. Immunization with Epstein-Barr virus (EBV) peptide-pulsed dendritic cells induces functional CD8+ T-cell immunity and may lead to tumor regression in patients with EBV-positive nasopharyngeal carcinoma. Chemotherapy with gemcitabine-containing regimens for locally recurrent or metastatic nasopharyngeal carcinoma. Chia WK, Teo M, Wang WW, et al. It’s also important to follow recommended screening guidelines, which can help detect certain cancers early. The more radical techniques should be preferred in site of the endoscopic nasopharyngectomy, being the firsts much more radical and thus usable also for locally advanced diseases. Ciuleanu E, Irimie A, Ciuleanu TE, Popita V, Todor N, Ghilezan N. Capecitabine as salvage treatment in relapsed nasopharyngeal carcinoma: a phase II study. Menon S, Shin S, Dy G. Advances in cancer immunotherapy in solid tumors. Lim WT, Ng QS, Ivy P, et al. Elser C, Siu LL, Winquist E, et al. Further imaging tests may be done if you later develop any signs or symptoms that might be caused by a return of the cancer. … A phase II trial of erlotinib as maintenance treatment after gemcitabine plus platinum-based chemotherapy in patients with recurrent and/or metastatic nasopharyngeal carcinoma. Radiology. Learn more in Second Cancers After nasopharyngeal Cancer. Ann Oncol. Back to Journals » OncoTargets and Therapy » Volume 12, Management of recurrent nasopharyngeal carcinoma: current perspectives, Authors Perri F, Della Vittoria Scarpati G, Caponigro F, Ionna F, Longo F, Buonopane S, Muto P, Di Marzo M, Pisconti S, Solla R, Published 26 February 2019 Cisplatin in recurrent or metastatic nasopharyngeal carcinoma with cisplatin and continuous infusion of 5-fluorouracil and bleomycin recurrent. Site will not function whilst javascript is disabled some may last for a few weeks to months, for... 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